At Wingate’s Pharmacy, we specialize in preparing Low Dose Naltrexone (LDN) as a custom-compounded therapy based on a provider’s prescription. LDN has gained interest among healthcare professionals for its role in supporting patients with a range of chronic and immune-related conditions when standard therapies may not be sufficient or appropriate.
Because LDN is not commercially available in low doses, our compounding pharmacy can fill the gap, providing accurately measured formulations in the exact strength and form requested by your provider.
What Is Low Dose Naltrexone?
Naltrexone is traditionally used in higher doses to treat opioid or alcohol dependence. In significantly lower doses (typically between 0.5 mg and 4.5 mg), it is being explored by healthcare professionals for use to support immune system modulation, inflammation management, and neurological function.
How LDN Is Thought to Work
While its full mechanism is still under investigation, LDN is believed to work by:
- Temporarily blocking opioid receptors, prompting a rebound increase in the body’s production of endorphins
- Supporting immune system regulation
- Influencing inflammation signals in the brain (glial cells)
- Modulating pain perception and nervous system activity
These effects are being studied in relation to conditions such as autoimmune disorders, chronic pain, and certain neurological conditions. LDN requires careful formulation, which is where our compounding expertise comes in.
Below is a list of conditions that healthcare providers commonly explore Low Dose Naltrexone (LDN) for, based on off-label use and emerging research. These are not approved FDA indications, and patients should always consult with their healthcare provider before considering LDN for any condition.
Common Conditions Providers May Consider for Low Dose Naltrexone (LDN)
Neurological Conditions
- Multiple sclerosis (MS)
- Parkinson’s disease
- Amyotrophic lateral sclerosis (ALS)
- Alzheimer’s disease
- Fibromyalgia
- Chronic Fatigue Syndrome (ME/CFS)
- Complex regional pain syndrome (CRPS)
- Peripheral neuropathy
Chronic Pain & Inflammation
- Chronic regional pain
- Migraines
- Interstitial cystitis
- Endometriosis
- Vulvodynia
- Temporomandibular joint dysfunction (TMJ/TMD)
- Rheumatoid arthritis
- Osteoarthritis
Autoimmune Conditions
- Hashimoto’s thyroiditis
- Graves’ disease
- Systemic lupus erythematosus (SLE)
- Psoriasis
- Crohn’s disease
- Ulcerative colitis
- Celiac disease
- Sjögren’s syndrome
- Scleroderma
Immune-Related Conditions
- HIV/AIDS-related inflammation
- Chronic Lyme disease (post-treatment Lyme disease syndrome)
- Mast cell activation syndrome (MCAS)
Mental Health & Mood Disorders
- Depression (off-label adjunct)
- Anxiety (off-label adjunct)
- PTSD
- Autism spectrum disorders (ASD)
Other Conditions Being Explored
- Polycystic ovary syndrome (PCOS)
- Hormone imbalance-related symptoms
- Certain dermatologic concerns (e.g., eczema, pruritus)
Available Dosage Forms at Wingate’s Pharmacy
We prepare LDN in several patient-friendly options, including:
- Capsules (in strengths as low as 0.1 mg)
- Sublingual tablets
- Oral suspensions (especially useful for pediatric or sensitive patients)
- Transdermal creams (if oral administration is not preferred)
Each prescription is compounded specifically to your provider’s instructions, and we can customize formulas to avoid allergens, dyes, or fillers.
Frequently Asked Questions (FAQs)
Why can’t I get LDN at a regular pharmacy?
LDN is not commercially manufactured in the low doses often prescribed for off-label uses. Because of this, it must be compounded by a pharmacy that specializes in customized formulations, such as Wingate’s Pharmacy.
How do I take LDN, and when is the best time to take it?
Your provider will recommend your dose and timing. Some patients are directed to take LDN at night to align with natural endorphin cycles, but individual schedules may vary. Follow your provider’s specific guidance on your prescription.
Can LDN be used with other medications or supplements?
It depends on the specific medication. LDN may interact with opioid-based medications and certain immune-modulating therapies. Always inform your provider of all medications and supplements you’re taking.
How long does it take to see changes with LDN?
Because LDN is prescribed for a variety of conditions, the timeline for potential changes varies. Your healthcare provider will monitor your response and make any needed adjustments to your dosage over time.
Is there a standard dose of LDN?
No. The dose is often customized based on the condition being addressed and the individual’s response. Starting doses may be as low as 0.5 mg and gradually increased under your provider’s supervision.
How should LDN be stored?
LDN capsules should be stored in a cool, dry place away from light and moisture. Liquid suspensions may require refrigeration. We will label each prescription with proper storage instructions.
Can LDN be flavored if my child or I have trouble with capsules?
Yes. We can compound LDN into flavored suspensions with kid-friendly or adult-approved options, free of dyes or unnecessary additives.
Personalized Service You Can Count On
If your healthcare provider has prescribed Low Dose Naltrexone, Wingate’s Pharmacy is here to prepare your medication with precision, care, and customization. Our compounding pharmacists are available to answer your questions and help support your treatment plan.
Contact us today to learn more or ask your provider to send in a prescription to Wingate’s Pharmacy.